Light can easily penetrate through holes in macroscopic openings such as windows, however openings that are comparable in size to the wavelength of light are difficult to penetrate. Scientists at Northwestern have demonstrated that light can squeeze through holes that are significantly smaller than the wavelength of light by using thin gold films that support plasmon excitation and a diffraction effect known as the Rayleigh anomaly. The sensitivity of this effect to adsorbed molecules makes it possible to use it for a new class of biomolecular sensing.
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